In this webinar, we present an approach for building MOA-based, simple, ready-to-use GLP-1 and GLP-2 bioassays and discuss assay validation results from Eurofins BPT.
About the webinar
There is a tremendous need to generate therapeutics targeting metabolic and gastrointestinal diseases. By targeting GPCRs, glucagon-like peptide (GLP-1 and GLP-2) receptors, therapeutics can be developed to address these globally prevalent medical disorders. In particular, engineered recombinant agonist analogues targeting the GLP-1 receptor are FDA approved for managing type 2 diabetes, obesity and body weight disorders, while GLP-2 analogues have been under therapeutic focus for the treatment of short bowel syndrome, a serious unmet medical disorder. Several other novel GLP analogues, including biosimilar and biobetters, are in clinical development; however, existing assays for characterising their mechanism-of-actions (MOAs) are complex and require extensive development time.
Eurofins DiscoverX provides ready-to-use, functional bioassays qualified with marketed drugs that reflect the true MOA for the therapeutic action of GLP analogues. These bioassays are fit-for-purpose for implementation in QC lot-release testing for several analogues including liraglutide, exenatide and semaglutide and they help accelerate the time-to-market therapeutic development by six to nine months.
Eurofins BioPharma Product Testing (BPT) in Italy, a comprehensive laboratory service provider for the largest biopharma, independently evaluated Eurofins DiscoverX’s GLP-1 and GLP-2 bioassays kits and generated validation data under a GMP setting.